home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410b.zip
/
M94A0221.TXT
< prev
next >
Wrap
Text File
|
1994-10-08
|
3KB
|
40 lines
Document 0221
DOCN M94A0221
TI Comparison of vertical human immunodeficiency virus type 2 and human
immunodeficiency virus type 1 transmission in the French prospective
cohort. The HIV Infection in Newborns French Collaborative Study Group.
DT 9412
SO Pediatr Infect Dis J. 1994 Jun;13(6):502-6. Unique Identifier : AIDSLINE
MED/94359773
AB In the French prospective cohort study we compared the mother-infant
transmission rates of human immunodeficiency virus type 1 (HIV-1) and
human immunodeficiency virus type 2 (HIV-2). As of January 1, 1994, 86
infants born to 68 HIV-2-seropositive mothers have been included in the
cohort. Forty-one children had been followed up for more than 18 months
at the time of analysis. During the same period 1758 infants born to
1589 HIV-1-infected mothers were included; 419 mothers were of African
origin. One thousand one hundred fifteen children had a follow-up of 18
months or more; 260 of these were of African origin. The HIV-2
transmission rate, based on serologic status at 18 months, was 0% (95%
confidence interval, 0 to 11%). This was significantly lower than the
HIV-1 transmission rate of 21% (confidence interval, 16 to 26%) in
infants born to African mothers. The difference remained significant
when the comparison was extended to HIV-1-positive women of French
origin infected by the sexual route or by iv drug abuse. Most of the
HIV-2-infected women were from West Africa; they were older and had more
children than the HIV-1-infected women. The circulating CD4+ lymphocyte
count was significantly higher in these women than in the HIV-1-infected
mothers. Reported differences in the replication of the two viruses
probably account for the lower mother-infant transmission rate of HIV-2.
DE Adult Africa/ETHNOLOGY AIDS Serodiagnosis Cohort Studies Comparative
Study Female France/EPIDEMIOLOGY Human HIV
Infections/*CONGENITAL/EPIDEMIOLOGY/IMMUNOLOGY/*TRANSMISSION
*HIV-1/IMMUNOLOGY *HIV-2/IMMUNOLOGY Infant Infant, Newborn Pregnancy
Pregnancy Complications, Infectious/EPIDEMIOLOGY/*IMMUNOLOGY
Prospective Studies Support, Non-U.S. Gov't Virus
Replication/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).